“PreMetabo” is a user friendly software to predict metabolism of drug molecules for helping users to make decision in early stage. It is named by a combination of words ‘prediction’ and ‘metabolism.’ ADME (Absorption, Distribution, Metabolism, and Excretion) properties of drugs or toxicants has been studied to understand their behaviour in human. The software is specifically focused on drug metabolism prediction in the liver. Metabolism prediction results of the software will be useful to understand pharmacodynamic properties of drug and properties related with drug metabolism. Modules in the software predicts selectivity of drug metabolism, site of metabolism, and transport of molecules. Furthermore, the software is designed that users can easily handle each module according to user’s needs, so that each user can easily select and use the modules. Therefore, we expect that PreMetabo will be useful software for the researches such as early phase removal of inappropriate candidates in drug discovery, improving bioavailability of drug molecules, and so forth.
Link : https://premetabo.bmdrc.kr/