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cellspacing="0" cellpadding="0"> <tr> <td colspan="3" height="1" background="/cgi/Counter/images/line260.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></td> </tr> <tr> <td width="30" align="middle"><img src="/cgi/Counter/images/ico_counter.gif" width="14" height="16"></td> <td width="50"><font size="1" face="Verdana"> TOTAL</font></td> <td> <span id="bmdSubMenu_myCounter_LabelTotalCount">56616690</span></td> </tr> <tr> <td colspan="3" height="1" background="/cgi/Counter/images/line260.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></td> </tr> <tr> </tr> </table> </td> </tr> <tr> <td height="80%"></td> </tr> </table> </TD> <TD width="1" background="/images/ver_line.gif"><IMG height="5" src="/images/ghost.gif" width="1" border="0"></TD> <TD vAlign="top"> <TABLE cellSpacing="0" cellPadding="4" width="599" border="0"> <TR> <TD width="12" rowspan="2"><img src="/images/ghost.gif" width="12" height="30" border="0"></TD> <TD> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td><img src="../images/m_gsk3b.gif" width="400" height="50"></td> </tr> <tr> <td background="/images/dot_h.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></td> </tr> <tr> <td height=25><a href="#gsk3b">GSK3?/a> | <a href="#structure">Structure</a> | <a href="#inhibitors">Inhibitors</a></td> </tr> <tr> <td background="/images/dot_h.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></td> </tr> </table></TD> </TR> <TR> <TD>  <p><img src="../../../images/bullets/s_purple.gif" width="14" height="15" align="absmiddle"><a class="s_kath_menu" name="cdk2"> Glycogen Synthase Kinase 3?a name="gsk3b" id="gsk3b"></a></p> <table width="400" border="0" align="center" cellpadding="0" cellspacing="0"> <tr> <td align="center"><img src="../images/neuro.jpg" width="300" height="352"></td> </tr> <tr> <td align="center"><h5>Fig 1. GSK3?Signal Transduction</h5> <ul> <li> <div align="left"><em>Brain Research Reviews</em> <strong>33</strong> (2000) 1-12</div> </li> <li> <div align="left"> <em>Current Opinion in Neurobiology</em> <strong>12</strong> (2002) 275-278</div> </li> </ul></td> </tr> </table> <ul> <li>Serine / Threonine kinase</li> <li> Alpha & beta forms <ul> <li> 97% homologous</li> </ul> </li> <li>Wnt signal pathway </li> <li>Neurodegenerative disease <ul> <li>Phosphorylation on TAU protein </li> <li>Related to b-catenin</li> </ul> </li> <li>Alzheimer's disease<br> </li> </ul> <p align="right"><a href="#"><img src="/images/bullets/s_top.gif" width="40" height="11" border="0"></a></p> <p><img src="../../../images/bullets/s_purple.gif" width="14" height="15" align="absmiddle"><a class="s_kath_menu" name="inhibitors"> Structure<a name="structure" id="structure"></a></p> <table width="350" border="0" align="center" cellpadding="0" cellspacing="0"> <tr> <td align="center"><img src="../images/gsk3b2.jpg" width="400" height="411"></td> </tr> <tr> <td align="center"><h5>Fig 2. Schematic view of GSK3β (1H8F)</h5></td> </tr> </table> <ul> <li>Molecular switches <ul> <li>뱋n?state and 뱋ff?state</li> <li>Transferation of the g-phosphate of ATP <ul> <li>To the hydroxyl group of serine, threonine, or tyrosine</li> </ul> </li> </ul> </li> <li>Two sub-domain, N lobe and C lobe <ul> <li>N lobe: five beta strand and one prominent aC helix</li> <li>C lobe: Helical</li> <li>ATP is bound in a deep cleft between the two lobes</li> </ul> </li> <li>P Loop <ul> <li>Glycine-rich sequence motif (GXGXfG)</li> <li>ATP Binding Loop</li> </ul> </li> <li>Activation loop and aC helix <ul> <li>key regulatory elements</li> <li>Activation loop stabilizes in an open and extended conformation by phosphorylation</li> </ul> </li> </ul> <p align="right"><a href="#"><img src="/images/bullets/s_top.gif" width="40" height="11" border="0"></a></p> <p><img src="../../../images/bullets/s_purple.gif" width="14" height="15" align="absmiddle"><a class="s_kath_menu" name="inhibitors"> Known Inhibitors</p> <blockquote> <p><img src="../images/gsk3b_inhibitors.gif" width="500" height="218"></p> <p><em>* J. Med. Chem</em>., 2003, <strong>46</strong>(15); 3333-3341 </p> </blockquote> <p align="right"><a href="#"><img src="/images/bullets/s_top.gif" width="40" height="11" border="0"></a></p>  </TD> </TR> </TABLE></TD> <TD width="1" background="/images/ver_line.gif"><IMG height="5" src="/images/ghost.gif" width="1" border="0"></TD> </TR> </TABLE> <table width="750" border="0" cellspacing="0" cellpadding="0"> <TR> <TD width="1" background="/images/ver_line.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></TD> <TD width="748" background="/images/ver_line.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></TD> <TD width="1" background="/images/ver_line.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></TD> </TR> <tr> <td width="1" background="/images/ver_line.gif"><img src="/images/ghost.gif" width="1" height="5" border="0"></td> <td width="748"><table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td height="10"><img src="/images/ghost.gif" width="5" height="10" border="0"></td> </tr> <tr> <td><table width="100%" border="0" cellspacing="0" cellpadding="4"> <tr> <td rowspan="2" width="136" align="right"><img src="/images/footer/logo_bmdrc.gif" width="70" height="54"></td> <td rowspan="2" width="1"><img src="/images/footer/ver_dote.gif" width="1" height="40"></td> <td height="25"><a href="/en/about/">About</a> | <a href="/en/about/contactinfo.aspx">Contact Info.</a></td> </tr> <tr> <td height="30" class="copyright">Copyright 2002-2003 ⓒ Research Institute of Bioinformatics & Molecular Design <br> ALL Right Reserved<br> B138A, Yonsei Engineering Research Complex, Yonsei University <br> 134 SinChon-dong, Seodaemun-gu, Seoul 120-749, Korea <br> TEL : 82-2-393-9550~1 FAX : 82-2-393-9554 </td> </tr> </table> </td> </tr> <tr> <td height="10"><img src="/images/ghost.gif" width="5" height="10" border="0"></td> </tr> </table> </td> <td width="1" background="/images/ver_line.gif"><img src="/images/ghost.gif" width="1" height="5" border="0"></td> </tr> <TR> <TD width="1" background="/images/ver_line.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></TD> <TD width="748" background="/images/ver_line.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></TD> <TD width="1" background="/images/ver_line.gif"><img src="/images/ghost.gif" width="1" height="1" border="0"></TD> </TR> </table> </form> </TR> </TABLE> </body> </html>